The Science

The research behind what we make - and why it matters.

Contents
Our approach

Clarity over claims.

The supplement industry runs on promises. We run on research. Every ingredient in every Longevity formula was selected because the clinical evidence is there - peer-reviewed, peer-replicated, and dosed at levels consistent with the data, not at label-dressing amounts that make the bottle look impressive.

We don't add ingredients because they're trending. We add them because they work. This page explains what we chose, why we chose it, and the science behind each formulation decision. If you have questions, we'll share the full reference list.

Our selection criteria

Three gates. Every ingredient.

Every ingredient in a Longevity product has to clear three criteria before it makes the formula. These aren't marketing standards. They're the questions a rigorous researcher would ask.

01

Criterion 1 - Clinical evidence at meaningful doses

We look for peer-reviewed research showing that the ingredient produces a measurable, relevant effect in humans - not just in cell culture or animal models. And we look specifically at the doses used in those studies, because an ingredient that works at 500 mg and is dosed at 50 mg is not the same thing. Longevity products are formulated at doses consistent with the clinical research.

02

Criterion 2 - Dose match to the studies

Premium supplements made with clean, carefully selected ingredients, clinically meaningful doses, and uncompromising manufacturing standards. We match our formulations to the data. The amounts in our Supplement Facts panels reflect actual study doses, not label-dressing minimums.

03

Criterion 3 - Third-party testing for purity and potency

Every Longevity product is manufactured in a cGMP-certified facility. We require independent third-party testing to verify that what's on the label is what's in the bottle - no more, no less. Certificates of analysis are on file.

Our current line covers five ingredients across three products. Each one was chosen to address a different pillar of healthy aging: bone and immune support, cardiovascular and cognitive health, and nervous system and sleep. Here's the science behind each.

Quality you can verify

We don't ask you to take our word for it.

Every Longevity product is manufactured under cGMP (current Good Manufacturing Practice) standards - the FDA's framework for dietary supplement manufacturing that governs everything from facility sanitation to raw material testing to finished-product batch verification.

We require third-party testing on each product: independent laboratory verification that what's on the label is what's in the bottle. Certificates of analysis are on file and are available on request.

Quality standards - confirmed across the line
StandardStatus
cGMP Certified Facility ✓ Confirmed - all Three products
Third-Party Tested ✓ Confirmed - COA on file for D3+K2, Magnesium, and Omega-3
Made in USA ✓ Confirmed
Allergen Declaration on Label ✓ Confirmed per product
Vitamin D3 + K2 · Bone, immune & cardiovascular support

How D3 and K2 work - and why they belong together.

Vitamin D3 (cholecalciferol) supports calcium absorption in the gut, which is foundational to bone density and immune function. But D3 alone presents a problem: when the body absorbs more calcium, that calcium needs somewhere to go. Without adequate Vitamin K2, absorbed calcium can deposit in soft tissues, including the arterial walls, rather than in bone.

Vitamin K2 - specifically the all-trans MK-7 form - activates two proteins critical to calcium regulation: osteocalcin, which binds calcium to bone mineral, and Matrix Gla Protein (MGP), which inhibits calcium from depositing in arteries and other soft tissues. The result is a complementary mechanism: D3 brings calcium in; K2 makes sure it ends up in the right place.

Together, they support bone mineral density, immune function, and cardiovascular health - particularly important for adults over 50, when both D3 synthesis in the skin (from sunlight) and dietary K2 intake tend to decline.
Our formula
  • D3: 5,000 IU (125 mcg) as cholecalciferol from algal (plant-derived) source - Vegan
  • K2: 100 mcg as all-trans MK-7 (Vitamin K2 VITAL)
  • Carrier: Organic coconut oil and non-GMO MCT oil in a veggie softgel
  • Allergen: Contains tree nuts (coconut)
  • Serving: 1 softgel daily
Plain-language summary

Most adults over 50 are deficient in both D3 and K2. D3 is synthesized from sunlight, and most people in northern latitudes - or who spend most of their time indoors - don't get enough. K2 is found primarily in fermented foods that most Western diets don't include. The combination addresses both gaps in a single softgel, at doses consistent with the clinical research on bone and cardiovascular outcomes.

Key studies
  1. Méndez-Sánchez L et al. (2023). Calcium and vitamin D supplementation for increasing bone mineral density. Cochrane Database of Systematic Reviews. PMID: 36705288
  2. Bischoff-Ferrari HA et al. (2020). Effect of Vitamin D Supplementation, Omega-3 Fatty Acid Supplementation, or a Strength-Training Exercise Program on Clinical Outcomes in Older Adults: The DO-HEALTH Randomized Clinical Trial. JAMA, 324(18):1855–1868. PMID: 33170239
  3. Knapen MH et al. (2013). Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women. Osteoporosis International, 24(9):2499–2507. PMID: 23525894
  4. Hariri E et al. (2021). Vitamin K2-a neglected player in cardiovascular health: a narrative review. Open Heart, 8(2):e001715. PMID: 34785587
  5. Diederichsen SZ et al. (2022). Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial. Circulation, 145(18):1387–1397. PMID: 35465686
Omega-3 Fish Oil · Heart, brain & inflammation support

EPA and DHA: the two omega-3s your body can actually use.

Not all omega-3s are equal. The omega-3 fatty acids that produce clinically studied cardiovascular, cognitive, and inflammation-related effects are the long-chain forms: EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid). Alpha-linolenic acid (ALA), found in plant sources like flaxseed, must be converted to EPA and DHA by the body - a conversion that is highly inefficient, particularly in older adults.

EPA (1,200 mg per serving) is the omega-3 most associated with cardiovascular health, including supporting healthy triglyceride levels and a balanced inflammatory response. EPA is a precursor to a class of signaling molecules that help regulate the body's inflammatory cascade.

DHA (900 mg per serving) is a primary structural component of the brain and retina. It makes up a significant proportion of the gray matter in the brain and is the dominant omega-3 in neural tissue. Adequate DHA is associated with cognitive function and visual health, particularly relevant as DHA levels in neural tissue can decline with age.

Combined, our formula delivers 2,100 mg of EPA + DHA per serving from a 3,000 mg cold-water fish oil base (anchovy and sardine), plus 150 mg of other omega-3 fatty acids.
Our formula
  • Fish Oil: 3,000 mg per serving
  • EPA: 1,200 mg per serving
  • DHA: 900 mg per serving
  • Other omega-3 fatty acids: 150 mg
  • Source: Cold-water anchovy and sardine, finished with natural lemon oil
  • Not vegan - softgel contains gelatin
  • Allergen: Contains fish (anchovy, sardines)
  • Serving: 3 softgels daily with a meal
Plain-language summary

Many fish oil supplements are mostly filler - a large oil base with a small concentration of the omega-3s that actually have clinical research behind them. This formula concentrates EPA and DHA: 2,100 mg of the two long-chain omega-3s per serving from a 3,000 mg base. For adults over 50, where dietary omega-3 intake from whole fish often falls short, concentrated EPA + DHA supplementation is one of the most studied nutritional interventions for cardiovascular and cognitive support.

Key studies
  1. Liu QK. (2021). Triglyceride-lowering and anti-inflammatory mechanisms of omega-3 polyunsaturated fatty acids for atherosclerotic cardiovascular risk reduction. Journal of Clinical Lipidology, 15(4):556–568. PMID: 34172393
  2. Arellanes IC et al. (2020). Brain delivery of supplemental docosahexaenoic acid (DHA): A randomized placebo-controlled clinical trial. EBioMedicine, 59:102883. PMID: 32690472
  3. Calder PC. (2017). Omega-3 fatty acids and inflammatory processes: from molecules to man. Biochemical Society Transactions, 45(5):1105–1115. PMID: 28900017
  4. Denis I et al. (2013). Omega-3 fatty acids and brain resistance to ageing and stress: body of evidence and possible mechanisms. Ageing Research Reviews, 12(2):579–594. PMID: 23395782
  5. Harris WS et al. (2013). Omega-3 fatty acids and cardiovascular disease: new developments and applications. Postgraduate Medicine, 125(6):100–113. PMID: 24200766
Magnesium Glycinate · Sleep, relaxation & nervous-system support

The mineral most adults don't get enough of - in the form that's gentlest to absorb.

Magnesium is involved in over 300 enzymatic processes in the body, including those governing muscle and nerve function, protein synthesis, blood glucose regulation, and energy metabolism. It plays a specific role in the regulation of the nervous system and in sleep architecture - insufficient magnesium is associated with disrupted sleep and heightened sympathetic nervous system activity.

Not all forms of magnesium supplement are equivalent. Magnesium oxide, the cheapest and most common form, has low bioavailability - much of it passes through the gut without being absorbed, and it can cause gastrointestinal discomfort. Magnesium glycinate - magnesium chelated to the amino acid glycine - is chosen for its higher absorption and its tolerance profile. Glycine itself has mild inhibitory properties that complement magnesium's role in nervous system relaxation.

This formula pairs magnesium glycinate with two supporting actives:

  • Taurine (100 mg) - an amino acid that complements magnesium in supporting calm and nervous-system balance
  • Vitamin B6 as P-5-P (5 mg, 294% DV) - the active pyridoxal-5-phosphate form, which plays a role in neurotransmitter synthesis and magnesium metabolism
Our formula
  • Magnesium (as glycinate): 250 mg per serving (60% Daily Value)
  • Taurine: 100 mg per serving
  • Vitamin B6 (as Pyridoxal-5-Phosphate / P-5-P): 5 mg per serving (294% Daily Value)
  • Vegan. Gluten-free. cGMP certified facility. Made in USA.
  • Serving: 3 veggie capsules daily, preferably with food (many prefer evening)
Plain-language summary

Magnesium deficiency is common in adults over 50, driven by both insufficient dietary intake and age-related changes in absorption. The form matters: glycinate is gentler and better absorbed than the oxide and carbonate forms found in most mass-market supplements. The addition of taurine and active B6 rounds out a formula built specifically around nervous system calm, sleep support, and the downstream effects of adequate magnesium at the cellular level.

Key studies
  1. Schuster J et al. (2025). Magnesium bisglycinate improves sleep quality in healthy adults with poor sleep: a randomized, double-blind, placebo-controlled trial. Nutrients. PMID: 40918053
  2. Zhang W, Zhao Y. (2025). Prevalence and trends of magnesium deficiency in the US adult population. Biological Trace Element Research. PMID: 41504160 Passarelli MN et al. (2024). Journal of Nutrition. PMID: 39218000
  3. Stanojevic V et al. (2025). Magnesium and the nervous system: mechanisms of action and clinical implications. Magnesium Research. PMID: 38709369
Inflammaging explained

The slow burn behind most age-related health decline.

"Inflammaging" (a portmanteau of "inflammation" and "aging") describes a phenomenon that's increasingly being documented in aging research: a state of chronic, low-grade, systemic inflammation that develops gradually as we age and that underlies or accelerates many of the health changes associated with getting older.

Unlike acute inflammation, which resolves once the threat of injury or infection is addressed, inflammaging is persistent and non-resolving. Immune cells become dysregulated with age, producing elevated levels of pro-inflammatory signaling molecules (cytokines) even in the absence of a specific threat. This background inflammation isn't dramatic enough to produce obvious symptoms in its early stages, but it is now associated in the research literature with a range of age-related changes in immune, cardiovascular, neurological, and metabolic function.

Why does inflammaging matter for supplementation? The ingredients in the Longevity line were not chosen randomly. Each one has research linking it to pathways relevant to the aging immune and inflammatory environment:

  • Vitamin D3 and K2 are both associated with immune regulation and the modulation of inflammatory pathways.
  • EPA from Omega-3 is a precursor to anti-inflammatory eicosanoids and is one of the most studied nutrients in the context of the body's inflammatory balance.
  • Magnesium, the deficiency of which is common in older adults, is associated with elevated markers of low-grade inflammation.
  • Mushroom-derived beta-glucans are recognized by pattern-recognition receptors on innate immune cells and are studied in the context of immune modulation in older adults.
  • Quercetin phytosome delivers a flavonol in a form the body absorbs efficiently, studied in relation to antioxidant and inflammatory pathways.
  • Fermented Wheat Germ Extract is studied for its role in cellular metabolic function and antioxidant support, both of which are relevant to the cellular environment that inflammaging creates.

Inflammaging is not a disease. It's a process. And like most processes, it's more effectively addressed earlier and consistently than reactively. That's the case for a daily, foundational supplement routine built on evidence-based ingredients.

Key references
  1. Franceschi C, Campisi J. (2014). Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. The Journals of Gerontology: Series A, 69(Suppl 1):S4–S9. PMID: 24833586
  2. Franceschi C et al. (2018). Inflammaging: a new immune–metabolic viewpoint for age-related diseases. Nature Reviews Endocrinology, 14(10):576–590. PMID: 30046148

See how the products fit together.

The science explains what we chose and why. The Longevity Plan puts it together into a daily routine - D3+K2, Omega-3, and Magnesium delivered monthly.
Explore The Longevity Plan Browse individual products